Endocrine Abstracts

Background: Appendiceal neuroendocrine tumours (aNETs) are usually diagnosed incidentally at appendicectomy, are indolent and rarely recur. Current ENETS guidelines inform aNETs management and highlight areas of uncertainty. We aimed to identify risk factors that predict lymph node metastasis, residual disease at completion surgery, or disease recurrence and also assessed survival according to ENETS stage.Methods: We retrospectively analysed a prospectiv...

Population and methodology: Patients with profound hyponatraemia (serum Na ≤125 mmol/l) admitted 1 November 2014 to 30 April 2015 were identified using hospital admission registry, laboratory’s database and qualitative data from the patients’ electronic records. Discharge summaries and death certificates were reviewed.Objectives: This is a retrospective audit set to asses: i) whether initial investigations of hyponatraemia were performed ...

Background: We previously published data for short-term outcomes in patients with SIADH-related hyponatraemia unresponsive to fluid restriction and treated with tolvaptan. In light of concerns over longer-term side-effects we have revisited the topic and extended both group size and follow-up period to determine longer-term safety and treatment implications.Aims/methods: We report ongoing treatment outcomes (case-note review) for 25 patients (age 71&#177...

We report potential effects of antituberculosis (TB) treatment on vitamin D metabolism in the immediate postoperative period following total thyroidectomy.A 50-year woman of Chinese origin was incidentally found to have papillary thyroid carcinoma with local nodal metastasis following FDG–PET imaging done to assess nature of lung nodules on chest X-ray and CT chest. The nature of lung lesion was uncertain and commenced on empirical TB treatment (fou...

Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).Objective: To determine the impact of IBD on pubertal status and pubertal growth.Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and b...

Introduction: Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. It is important to recognise pituitary dysfunction following TBI as it can cause significant morbidity.Methods: 179 TBI patients (137 males) age 41.0±15.7 years (17.6–88.1 years) attended Charing Cross Hospital clinic (July 2009–August 2011). Median time since TBI was 0.27years (0.05–46.5 years, 26% >1 years). 34% had an intrac...

Background: Puberty is understood to be commonly effected in adolescents with Crohn’s Disease (CD) and ulcerative colitis (UC). However, the extent of this effect and related problems with growth, have rarely been quantified.Objective: To determine the impact of CD and UC on pubertal growth.Methods: Retrospective study of 148 children with IBD (casenotes available, 135) who fulfilled the criteria for describing growth spurt pa...

Introduction: Treatment with anti-TNFα therapy such as infliximab may improve growth in children with CD but the extent of improvement in growth and its relationship to pubertal progress and changes in glucocorticoid therapy are unclear.Aim: A retrospective study of growth, puberty and disease activity over the 6 months prior (T−6) to starting infliximab, at baseline (T0) and for the following 6 months (T+6) in CD. Results are expressed as med...

Background: Whilst puberty is understood to be commonly effected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC), the extent of this effect as well as related problems with growth have rarely been quantified.Objective: To determine the impact of CD and UC on Size, Tempo and Velocity of the growth spurt.Methods: Retrospective study of 142 children with IBD (case notes available, 68) who fulfilled the criter...

Introduction: A joint RAI clinic, led by an endocrinologist and nuclear physicist, was introduced in our centre, in July 2007.Aims: To compare our practice since the introduction of the joint RAI clinic against guidelines from the Royal College of Physicians of London.Methods: A retrospective audit of patients who received RAI, Sept 2007–Oct 2008. Data collected from patients’ case notes and compared to previous audit 200...